implications for hiv 1 pathogenesis and infectivity
Báo cáo hóa học: " Expression of HIV receptors, alternate receptors and co-receptors on tonsillar epithelium: implications for HIV binding and primary oral infection" doc
... 76(3) :10 04 -10 14 Orentas RJ, Hildreth JE: Association of host cell surface adhesion receptors and other membrane proteins with HIV and SIV AIDS Res Hum Retroviruses 19 93, 9 (11 ) :11 57 -11 65 Fortin ... erosexual, HIV- 1- discordant couples in Rakai, Uganda Lancet 20 01, 357(9263) :11 49 -11 53 Royce RA, Sena A, Cates WJ, Cohen MS: Sexual transmission of HIV N Engl J Med 19 97, 336 (15 ) :10 72 -10 78 Fotopoulos ... model for HIV pathogenesis Nat Med 19 95, 1( 12) :13 20 -13 22 Glushakova S, Baibakov B, Zimmerberg J, Margolis LB: Experimental HIV infection of human lymphoid tissue: correlation of Page 11 of 13 (page...
Ngày tải lên: 20/06/2014, 01:20
báo cáo hóa học:" Gender and sexuality: emerging perspectives from the heterosexual epidemic in South Africa and implications for HIV risk and prevention" pdf
... Masculinities and multiple-sexual-partners in KwaZulu-Natal: The Making and Unmaking of Isoka Transformation 2004, 54 :12 3 -15 3 doi :10 .11 86 /17 58-2652 -13 -6 Cite this article as: Jewkes and Morrell: Gender and ... Prevention, Cape Town; 19 -22 July 2009 Jewkes and Morrell Journal of the International AIDS Society 2 010 , 13 :6 http://www.jiasociety.org/content /13 /1/ 6 Page 11 of 11 69 Coetzee D, Hildebrand K, Boulle ... (aOR) of 1. 89 (1. 20, 2.96) in Rwanda, and 2.39 (1. 21, 4.73) in Tanzania [12 ,13 ] The Tanzanian study was conducted among women in a clinic offering voluntary testing and counselling, and it also...
Ngày tải lên: 20/06/2014, 08:20
Báo cáo khoa học: " Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success" potx
... Virology Journal 2009, 6 :18 4 http://www.virologyj.com/content/6 /1/ 184 A Combination marker M M CM M 2.0 kb 1. 5 1. 0 0.75 0.5 Population # 11 12 13 14 10 16 17 18 19 15 M 21 22 23 24 Not detected ... profiles for each scenario modeled Scenario 6× 10 0 90 50 0 % of cells with combinations of the indicated shRNA number per scenario 5× 4× 3× 2× 0 0 10 0 0 10 0 2 2 10 10 10 10 90 50 20 15 1 0 10 15 The ... http://www.FigureMeHappy.com References 10 11 12 13 14 Competing interests 15 This work was done by employees of Johnson and Johnson Research (JJR), except for J M M who performed consulting for JJR 16 Zamore PD, Haley...
Ngày tải lên: 12/08/2014, 04:20
Báo cáo y học: ""Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence" doc
... Biol Interact 19 94, 91: 111 -12 1 Anderson ME: Glutathione: an overview of biosynthesis and modulation Chem Biol Interact Chem Biol Interact 19 98 Apr 24 ;11 111 2 :1- 14 19 98, 11 1 -11 2 :1- 14 Zhao M, Rudek ... type promoter J Virol 2007, 81: 10 914 -10 923 Page of 10 (page number not for citation purposes) Retrovirology 2009, 6:52 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 Khan N, Jeffers ... here for file [http://www.biomedcentral.com/content/supplementary /17 424690-6-52-S2.ppt] 10 11 12 13 14 Hamer DH: Can HIV be Cured? Mechanisms of HIV persistence and strategies to combat it Curr HIV...
Ngày tải lên: 12/08/2014, 23:21
Báo cáo y học: " siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication" potx
... to knockout HIV- 1 Cell 2008, 13 5: 417 -420 10 11 12 13 14 15 16 Cherry S: What have RNAi screens taught us about viral-host interactions? Curr Opin Microbiol 2009, 12 :1- 7 Brass AL, Dykxhoorn DM, ... http://www.retrovirology.com/content/6 /1/ 78 Table 1: Selected HIV- 1 cofactors identified in the siRNA and shRNA screens Gene name Protein function Possible role in HIV- 1 life cycle MED4 MED7 MED14 MED28 NUP98 NUP155 NUP 210 GCC1 ... different HIV- 1 cofactors in the screens [1] Figure for HIV- 1 replication cofactors A comparison between siRNA- and shRNA-based screens A comparison between siRNA- and shRNA-based screens for HIV- 1 replication...
Ngày tải lên: 12/08/2014, 23:22
Tài liệu Báo cáo khoa học: Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters docx
... 50 1. 20 66 626 8 .1 (44.2) 11 .3 (2.5) 91. 6 (62.7) 10 1. 20 16 .4 20 .1 1 51 (12 9.8) 57.95 86. 01 46. 21 50 1. 29 55 569 7.0 (40.2) 15 .2 (2.3) 93.9 (70.4) 10 1. 29 15 .5 19 .3 17 7 (14 3.6) 58 .12 85. 91 46 .10 ... 46 .10 50 1. 16 73 638 7.2 (35.7) 20 .1 (2 .1) 91. 8 (58.9) 10 1. 16 15 .4 18 .8 242 (2 21. 5) 57.50 86.00 45.95 50 1. 50 37 010 6.0 (46.2) 16 .8 (2.4) 99.7 (99.2) 10 1. 50 14 .9 19 .7 15 2 (12 8.5) 59. 51 86.88 ... (min )1) kcat ⁄ Km (lMÆmin )1) Relative kcat ⁄ Km Ki (nM) 30 65 10 9 41 43 73 13 19 0 12 0 68 300 13 0 320 950 6.5 1. 8 0.6 7.3 3 .1 4.4 73 1. 0 0.3 0 .1 1 .1 0.5 0.7 11 .2 0 .15 1. 5 4.5 0.50 0. 41 0.9 0 .16 ...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo Y học: Receptor crosstalk Implications for cardiovascular function, disease and therapy ppt
... crosstalk (Eur J Biochem 269) 4727 10 11 12 13 14 15 16 REFERENCES Dzimiri, N (19 99) Regulation of b-adrenoceptor signaling in cardiac function and disease Pharmacol Rev 51, 465–502 Bylund, D.B., Bond, ... of cardiac b-adrenergic receptors by 10 0 10 1 10 2 10 3 10 4 10 5 10 6 captopril Implications for congestive heart failure Circulation 80, 669–675 Gilbert, W.M., Sandoval, A., Larabee, P., Renlund, D.G., ... myocytes [11 ]; PKC-mediated depression of b-AR response to IPN in a1B-AR overexpressing mice [13 ,14 ] Attenuates a1-AR mRNA and stimulated c-fos induction [17 ] Phosphorylates a1B in Rat -1 fibroblasts...
Ngày tải lên: 21/02/2014, 15:20
Systematic bias in estimates of reproductive potential of an Atlantic cod (Gadus morhua) stock: implications for stock–recruit theory and management pptx
... (6.78 10 –4) 4 .10 10 15 (5.42 10 15 ) 0.73 (0. 41) 16 3.54 0.38 0.023 6.47 10 8 1. 78 10 14 97.38 (447.46) 1. 87 10 –6 (2.75 10 –6) 0.74 (0.43) 16 3. 31 0. 41 0. 014 6.63 10 8 396 990 7.82 10 (5 .18 10 ) 3 .17 10 –6 ... (5 .18 10 ) 3 .17 10 –6 (1. 58 10 –6) 1. 68 (0.56) 16 2.49 0.56 0.0 01 6.82 10 8 533 18 0 1. 01 10 (9.70 10 ) 1. 91 10 15 (3.09 10 15 ) 0.56 (0. 31) 50 20.80 0 .16 0. 011 7. 41 10 8 2.93 10 14 –4 FSB SSB TEP –2 ... 4.78 10 (1. 57 10 ) 1. 07 10 –6 (1. 40 10 –6) 0.60 (0.30) 50 20.43 0 .18 0.007 7.39 10 8 562 730 1. 61 (7.95) 1. 48 10 –6 (1. 03 10 –6) 1. 04 (0.42) 50 19 .44 0.22 0.002 7 .19 10 8 705 440 α β γ df RSS r2 P Rp...
Ngày tải lên: 14/03/2014, 16:20
Evaluating impacts of air pollution in China on public health: Implications for future air pollution and energy policies pptx
... (44%) (44%) À2662 (8%) À 817 59 (44%) (44%) À62 (8%) 18 90 (44%) À2 18 À5 15 7 À20 À756 17 (13 %) (13 %) (13 %) (13 %) (13 %) (13 %) (13 %) 17 50 À904 À423 À55 À404 18 7 13 2 17 À8 41 À523 À38 À5 Health ... 10 7 À26 À 219 À745 À200 À56 À856 À52 19 34 À29342 17 71 À245 À3 717 À224 À9307 14 117 0 À8520 À 215 À3263 11 97 Health damage costs (million 2000 US$) À200 À97 Deathb Illness b À80 13 À25 17 4 17 7 ... À2.0 1. 3 1. 1 A to B C to D C to E C to F SO2 65 224 11 5 15 2 Sulfates À47 À248 14 9 À 31 À0.7 1. 1 1. 3 À0.2 A to B C to D C to E C to F NOx 13 99 30 50 Nitrates À34 10 6 À2.7 1. 1 0.2 0.0 NMVOC...
Ngày tải lên: 15/03/2014, 20:20
Báo cáo khoa học: Functional analysis of cell-free-produced human endothelin B receptor reveals transmembrane segment 1 as an essential area for ET-1 binding and homodimer formation pptx
... novel selective ligands BQ -12 3 and [Ala1,3 ,11 ,15 ]ET -1 Biochem Biophys Res Commun 18 2, 14 4 15 0 40 Saeki T, Ihara M, Fukuroda T, Yamagiwa M & Yano M (19 91) [Ala1,3 ,11 ,15 ]Endothelin -1 analogs with ETB ... constant KD for binding of ETBcHx to bET -1 as 6.2 ± 1. 7 · 10 )9 (Fig 7) Similar assays with the C-terminal-truncated derivatives ETB1 31 and ETB93 revealed KD values of (2.7 ± 1. 9) · 10 )8 and (1. 7 ± ... kDa NTD T1 C1 T2 E1 T3 C2 T4 E2 T5 C3 T6 E3 T7 CTD C-terminal tag ETBDT7 ETBcHx ETBStrep ETB1 31 ETB168 ETB203 ETB306 ETB132 ETB204 ETB307 ETB93 M1–S443 Q2–S443 E27–S443 E27–C1 31 E27–P168 E27–V203...
Ngày tải lên: 16/03/2014, 10:20
Báo cáo khoa học: Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138 pot
... 0.089 E138K-PETT-2 SRS PX14.2 CCD ADSC-Q4 0.979 13 8.8, 11 4.8, 65.9 30.0–3.0 575 71 19095 88.0 11 .8 0.083 2.59–2.50 33 71 92.5 1. 0 2.59–2.50 3627 99.5 1. 1 3 .11 –3.00 15 37 72.6 1. 4 30.0–2.5 33264 ⁄ 17 40 ... K101E-nevirapine PF BL-6 A Fuji BAS III 1. 000 13 8.9, 11 4.9, 65.6 30.0–2.5 14 98 21 35057 94.4 9.8 0 .10 0 E138K-nevirapine APS SBC-2 CCD SBC 0.82657 13 9.6, 11 5.0, 65.6 30.0–2.5 2 516 96 3 710 4 99.5 12 .6 ... Lys101Glu in p66 and nevirapine (B) Glu138Lys in p 51 and nevirapine (C) Glu138Lys in p 51 and PETT-2 Fig 1, i.e for Lys101Glu in the p66 subunit (Fig 1A) and Glu138Lys in the p 51 subunit (Fig 1B,C) Comparison...
Ngày tải lên: 16/03/2014, 13:20
Báo cáo khoa học: Peptides that bind the HIV-1 integrase and modulate its enzymatic activity – kinetic studies and mode of action pptx
... 16 217 6 16 618 0 17 018 4 17 418 8 18 219 6 18 6200 210 224 214 228 218 232 222236 238252 242256 246260 HIV IN residues 9 410 7 9 811 6 12 614 5 13 014 9 13 915 3 15 116 5 16 317 7 16 718 1 17 919 3 18 72 01 1 912 05 19 5209 223237 ... 56 71 5678 5679 5680 56 81 5682 5683 5685 5686 5692 5693 5694 5695 5699 5700 57 01 a Sequence NIH no 3852 4256 6276 6680 7084 8296 9 410 8 9 811 2 11 012 4 11 813 2 12 213 6 12 614 0 15 416 8 15 817 2 16 217 6 16 618 0 ... Sci 31, 9 810 5 49 Engelman A, Mizuuchi K & Craigie R (19 91) HIV- 1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer Cell 67, 12 111 2 21 FEBS Journal 278 (2 011 ) 316 330 ê 2 010 ...
Ngày tải lên: 22/03/2014, 16:21
Báo cáo khoa học: HIV-1 gp41 and gp160 are hyperthermostable proteins in a mesophilic environment ppt
... (kcalÆmol )1) DHvH (kcalÆmol )1) DHvH/DHcal Reversibility (%) 11 0.4 11 9.5 10 9 .1 109 .1 112 .6 93.3 10 6.4 11 1.8 61 21 94 91 38 71 32 41 228 16 5 308 303 2 01 134 218 19 1 3.7 7.8 3.3 3.3 5.3 1. 9 6.8 4.6 ... (kcalÆmol )1) DHvH (kcalÆmol )1) DHvH/DHcal Reversibility (%) NC1 NC2 CN1 CN2 CN3 A30-D78_N 113 -K154 A30-K77_W 117 -K154 W 117 -K154_A30-K77 W 117 -A156_A30-K77 W 117 -W159_A30-K77 91. 0 86.5 10 1.9 10 6.8 11 2.5 10 3 ... W6OA/I124D/I131D/Q142N N-c/N-e L/L C-f/C-g C-g/C-d N-g/N-a/N-d N-d/N-d/C-a L/L/L N-f/C-a/C-a/C-e 11 0.4 11 2.6 97.8 92.8 96.0 10 5.3 10 5.5 10 8 .1 106.6 10 5.6 11 9 .1 106.2 10 8.0 71. 7 61 40 36 36 33 69 90 56 61...
Ngày tải lên: 30/03/2014, 13:20
báo cáo sinh học:" Health workers'''' views on quality of prevention of mother-to-child transmission and postnatal care for HIV-infected women and their children" docx
... manager 4 10 Doctor 4 16 Nurse 2 2 Midwife 0 Counsellor 4 13 16 11 16 10 53 Total Page of 11 (page number not for citation purposes) Human Resources for Health 2009, 7:39 Results External and internal ... workers and HIV/ AIDS: a critical review of the literature Social Sciences and Medicine 19 95, 41( 11) :15 35 -15 67 Mungherera M, Straten A van der, Hall TL, Faigeles B, Fowler G, Mandel JS: HIV/ AIDS ... especially for counselling, which takes a long time to well [12 ,19 -22] In the case of HIV and PMTCT, additional reasons for the unsatisfying performance included inadequate knowledge and skills...
Ngày tải lên: 18/06/2014, 17:20
Báo cáo hóa học: " Sargassum fusiforme fraction is a potent and specific inhibitor of HIV-1 fusion and reverse transcriptase" pot
... precipitation [19 ], with 10 µg of HIV- 1 clone DNA and 15 µg of VSV-G envelope expression plasmid DNA, a ratio of DNAs found to yield the highest HIV- 1 infectious titers in our hands For native HIV- 1 production, ... http://www.virologyj.com/content/5 /1/ 8 Figure Inhibition of X4 and R5-tropic HIV- 1 Inhibition of X4 and R5-tropic HIV- 1 GHOST X4/R5 and GFP expressing cells were plate at × 10 5/well in 12 -well plates and incubated at 37°C in CO2 ... pretreated with 0, 4, 8, 12 , and 24 µg/ml SP4-2, replicated HIV- 1 in a dose dependent manner that produced 10 61, 807, 544, 352, and 14 8 p24 pg/ml, respectively The HIV- 1 inhibition was calculated...
Ngày tải lên: 20/06/2014, 01:20
báo cáo hóa học:" HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study" pptx
... marker for the efficacy of anti-retroviral therapy in HIV- 1- infected patients in Thailand Virology 2005, 3 41: 238-247 25 CDC: 19 93 revised classification system for HIV infection and expanded surveillance ... http://www.jiasociety.org/imedia/3 310 067 016 319 189/supp3.ppt Additional file 4: Boehler Additional file edited.ppt, 421K http://www.jiasociety.org/imedia /15 913 257 316 319 19/supp4.ppt Additional file 5: ... peripheral blood T cells and CD4+ T cell counts in 13 2 treatment-naïve HIV- 1 infected patients (panels A, C and E) as well as HIV- 1 plasma viral load levels in 12 5 patients (panels B, D and F) living in...
Ngày tải lên: 20/06/2014, 08:20
Báo cáo y học: "A quantitative evaluation of gross versus histologic neuroma formation in a rabbit forelimb amputation model: potential implications for the operative treatment and study of neuromas" ppt
... (0.24) 12 1 817 0.049 mm proximally 13 27000 (1. 70) 9346 (1. 70) 16 .4 (0.43) 15 34 61 0 .11 6 10 mm proximally 82 510 0 (1. 05) 7445 (1. 36) 21. 5 (0.57) 16 0 216 0 .19 4 15 mm proximally 70 810 0 (0. 91) 6525 (1. 19) ... 74325 0.090 14 .7 (0.47) 10 9205 0 .16 8 16 .1 (0. 51) 87729 0.208 3463 (0.90) 27.7 (0.88) 95925 0.294 480300 (1. 00) 3839 (1. 00) 31. 5 (1. 00) 12 0967 0.252 Median Radial Distal end 2498000 (3 .19 ) 13 280 (2.42) ... < 0.00 01 for distal end, 5, 10 , and 15 mm proximally) and in the ulnar nerve (p < 0.00 01 for distal end, 5, 10 , and 15 mm group) Discussion Inspired by findings both in the laboratory and in...
Ngày tải lên: 10/08/2014, 10:20
Báo cáo y học: " Quantitative PCR used to Assess HIV-1 Integration and 2-LTR Circle Formation in Human Macrophages" potx
... 19 93, 67 :11 69 -11 74 10 Stevenson M, Stanwick TL, Dempsey MP, Lamonica CA: HIV- 1 replication is controlled at the level of T cell activation and proviral integration Embo J 19 90, 9 :15 51- 1560 11 ... immunodeficiency virus -1 (HIV- 1) J Clin Invest 19 92, 89 :17 6 -18 3 Butler SL, Hansen MS, Bushman FD: A quantitative assay for HIV DNA integration in vivo Nat Med 20 01, 7:6 31- 634 doi :10 .11 86 /17 43-422X-7-354 ... J Med 19 98, 339 :18 03 -18 09 Zhu T, Mo H, Wang N, Nam DS, Cao Y, Koup RA, Ho DD: Genotypic and phenotypic characterization of HIV- 1 patients with primary infection Science 19 93, 2 61: 117 9 -11 81 Gartner...
Ngày tải lên: 12/08/2014, 02:20
Báo cáo y học: " A novel trifunctional IgG-like bispecific antibody to inhibit HIV-1 infection and enhance lysis of HIV by targeting activation of complement" ppsx
... of two parts N Engl J Med 20 01, 344 :11 40 -11 44 Jia et al Virology Journal 2 010 , 7 :14 2 http://www.virologyj.com/content/7 /1/ 142 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 Walport MJ: ... factor H and properdin react with specific sites in gp120 and gp 41, the envelope proteins of HIV- 1 Immunobiology 19 95, 19 3:98 -11 3 Stoiber H, Clivio A, Dierich MP: Role of complement in HIV infection ... 20 01, 344 :11 58 -11 66 Stoiber H, Pruenster M, Ammann CG, Dierich MP: Complementopsonized HIV: the free rider on its way to infection Mol Immunol 2005, 42 :15 3 -16 0 Banki Z, Stoiber H, Dierich MP: HIV...
Ngày tải lên: 12/08/2014, 04:20
Báo cáo y học: " Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells" doc
... 0. 01 0.05 0 .1 0.5 10 0.05 ± 0. 01 0.06 ± 0. 01 0.09 ± 0. 01 0 .10 ± 0. 01 0 .12 ± 0. 01 0. 51 ± 0.02 1. 02 ± 0.08 1. 53 ± 0.09 1. 68 ± 0 .11 0.67 ± 0.04 1. 34 ± 0 .10 3.22 ± 0 .15 3.42 ± 0 .16 3.95 ± 0 .18 5 .13 ... ± 0. 41 10.98 ± 0.43 13 .83 ± 0. 61 16.66 ± 0. 71 21. 99 ± 0.94 30 .16 ± 1. 12 WT 0.04 ± 0. 01 0.08 ± 0. 01 0 .17 ± 0.02 0.39 ± 0.03 0.69 ± 0.05 1. 23 ± 0 .10 3.32 ± 0 .14 ΔRev 3.93 ± 0 .17 4.05 ± 0. 21 4.44 ... Virus (MOI 1) HeLa P4 WT ΔRev LEDGF/p75-knockdown 2.5 1. 02 ± 0.08 1. 04 ± 0.07 1. 25 ± 0.09 12 .5 62.5 10 0 15 0 200 2 .16 ± 0 .11 3.30 ± 0 .14 5 .16 ± 0.20 9.70 ± 0.43 18 .93 ± 0.74 8.82 ± 0.37 9 .13 ± 0.34...
Ngày tải lên: 12/08/2014, 04:20