htlv 1 tax contribute to cellular transformation

... http://www.retrovirology.com/content/5 /1/ 76 11 4 11 5 11 6 11 7 11 8 11 9 12 0 12 1 12 2 12 3 12 4 12 5 12 6 12 7 12 8 12 9 13 0 13 1 13 2 mediated through the SRC1-interacting domain of CBP/ p300 J Biol Chem 2002, 277:9054-90 61 Riou P, Bex ... NRF1 [88] p/CAF [10 1] p300/CBP [10 0] CasL [ 215 ] Cdc42 [13 0] Gap1m [13 0] GPS2 [18 3] Gβ2 [300] IKKα [15 9] IKKβ [15 9] IKKγ [15 6] IκBα [16 2] IκBγ [16 1] MEKK1 [15 7] p100 [ 317 ] p105 [16 3] p130Cas [ 215 ] ... [19 9] PP2A [16 8] Rac [13 0] RhoA [13 0] Smad2 [ 213 ] Smad3 [ 213 ] Smad4 [ 213 ] TAB2 [18 1] TAK1 [15 8] Tax1 BP1 [17 1] Ubc13 [17 0] p50 [ 61] PDZ proteins p52 [74] RelA [75] RPL6 [ 318 ] Sap1 [63] Sc35 [14 1]...

Ngày tải lên: 13/08/2014, 05:21

... of Health to C.-Z.G References 10 11 12 13 14 15 Zhao LJ, Giam CZ: Interaction of the human T-cell lymphotrophic virus type I (HTLV- I) transcriptional activator Tax with cellular factors that ... http://www.retrovirology.com/content/4 /1/ 35 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 human T-cell leukemia virus I Tax- mediated NF-kappaB activation J Biol Chem 19 98, 273: 211 32- 211 36 Xiao G, Cvijic ... specifically to the 21- base-pair repeats in the HTLV- I enhancer Proc Natl Acad Sci USA 19 91, 88 :11 445 -11 449 Zhao LJ, Giam CZ: Human T-cell lymphotropic virus type I (HTLV- I) transcriptional activator, Tax, ...

Ngày tải lên: 13/08/2014, 05:22

... D2, p18Ink4 and p21Waf1/Cip1/Sdi1 Oncogene 19 96, 12 :16 45 -16 52 Li J, Li H, Tsai M: Direct binding of the N-terminus of HTLV- 1 tax oncoprotein to cyclin-dependent kinase is a dominant path to stimulate ... into two daughter cells resulting in a percentage of cells with two or more centrosomes Page of (page number not for citation purposes) Retrovirology 2006, 3:50 10 11 12 13 14 15 16 17 18 19 ... centrosomes per cell HTLV Tax TaxBP1 81 RanBP1 Tax1 BP2 Mitotic spindle checkpoint protein Regulator of Ran-GTPase pathway Regulates centrosome duplication >2 centrosomes per cell Abnormal mitotic spindles...

Ngày tải lên: 13/08/2014, 09:20

... recombination Science 19 94, 265 :14 42 -14 45 Page of 10 (page number not for citation purposes) Retrovirology 2005, 2:45 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Kurimasa A, Ouyang ... the incubation the slides were immersed into a basin containing 0 .1% Triton X -10 0 and 0.5% BSA in HBS to equilibrate the slides with anti-DIG -11 -dUTP (1: 50) labelled with FITC (Boheringer) Equilibration ... laboratory for critical reading of manuscript, and Anthony Elmo for preparation of manuscript References 10 11 Majone F, Semmes OJ, Jeang KT: Induction of micronuclei by HTLV- I Tax Virology 19 93, 19 3:456-459...

Ngày tải lên: 13/08/2014, 09:21

... CDK4dH30-V72, CDK4dV70-L100, CDK4dR1 01- L120, CDK4dM1 21- S150, CDK4dS150-R1 81, CDK4dA182-K 211 , CDK4dK 211 -D2 41, CDK4dV242-M275 were created To engineer the N- terminal CDK4dM1-F 31 and C-terminal CDK4dL272E303 ... 5'-CAGCTTGACTGTTCCACCCACDK4dM1 21- S150AS, GATCCTTGATGGTTTC-3'; CDK4dS150-R181S, 5'-AACATTCTGGTGACAAGTGTTACACTCTGGTACCGA-3'; CDK4dS150-R181AS, 5'-TCGGTACCAGAGTGTAACACTTGTCACCAGAATGTT-3'; 5'-GCTCCCGAAGTTCTTCTCDK4dA182-K 211 S, ... infected T-cell lines: possible involvement of Tax1 in the altered expression of cyclin D2, p18Ink4 and p21Waf1/Cip1/Sdi1 Oncogene 19 96, 12 :16 45 -16 52 Santiago F, Clark E, Chong S, Molina C, Mozafari...

Ngày tải lên: 13/08/2014, 09:21

... [0 .1% SDS, 1% Triton X -10 0, mM EDTA, 20 mM Tris-HCl[pH8 .1] , 15 0 mM NaCl], buffer b [0 .1% SDS, 1% Triton X -10 0, mM EDTA, 20 mM Tris-HCl[pH8 .1] , 500 mM NaCl], buffer c [0.25 M LiCl, 1% NP-40, 1% ... loop of HTLV- 1 gene expression in infected cells, which may be one of the bases for the induction of HTLV1 latency Results HTLV- 1 Tax interacts with SUV39H1 To determine whether HTLV- 1 Tax has ... Tax, we used three kinds of mutants, TaxN180, Tax N108 and ∆CBP-B TaxN180 has a C-terminal deletion up to 18 0 amino acids, Tax N108 a deletion of N-terminal 10 8 amino acids and ∆CBP-B a deletion...

Ngày tải lên: 13/08/2014, 09:21

... Page of 11 (page number not for citation purposes) Retrovirology 2009, 6 :11 7 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, Igata A, Matsumoto M, ... changes in order to escape cell cycle arrest induced by Tax1 Tax3 and Tax4 Like HTLV- 1 and HTLV- 2, HTLV- 3 and HTLV- 4 encode Tax3 and Tax4 , respectively In their cognate viruses, Tax3 and Tax4 could ... HTLV- 2 Tax proteins In addition to structure genes, gag, pol, and env, HTLV- 1 encodes several non-structural genes including p12, p13, p30, Rex, and Tax (Figure 1) [17 ] Among them, HTLV- 1 Tax (Tax1 )...

Ngày tải lên: 12/08/2014, 23:22

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Ngày tải lên: 23/03/2014, 17:21

... interests Received: 13 April 2 011 Accepted: July 2 011 Published: July 2 011 References Higuchi M, Fujii M: Distinct function of HTLV- 1 Tax1 from HTLV- 2 Tax2 contributes key roles to viral pathogenesis ... paraparesis Lancet 19 85, 2:407- 410 12 Osame M, Usuku K, Izumu S, Ijichi N, Amitani H, Igata A, Matsumoto M, Tara M: HTLV- 1 associated myelopathy, a new clinical entity Lancet 19 86, 1: 10 31- 1032 13 Ross TM, ... Retrovirology 2009, 6 :11 7 -12 7 De Thé G, Kazanji M: An HTLV- I/II vaccine: from animal models to clinical trials? J Acquir Immune Defic Syndr Hum Retrovirol 19 96, 13 (Suppl 1) : S1 91- 198 Feuer G, Green...

Ngày tải lên: 18/06/2014, 22:20

... interests Received: 13 April 2 011 Accepted: July 2 011 Published: July 2 011 References Higuchi M, Fujii M: Distinct function of HTLV- 1 Tax1 from HTLV- 2 Tax2 contributes key roles to viral pathogenesis ... paraparesis Lancet 19 85, 2:407- 410 12 Osame M, Usuku K, Izumu S, Ijichi N, Amitani H, Igata A, Matsumoto M, Tara M: HTLV- 1 associated myelopathy, a new clinical entity Lancet 19 86, 1: 10 31- 1032 13 Ross TM, ... Retrovirology 2009, 6 :11 7 -12 7 De Thé G, Kazanji M: An HTLV- I/II vaccine: from animal models to clinical trials? J Acquir Immune Defic Syndr Hum Retrovirol 19 96, 13 (Suppl 1) : S1 91- 198 Feuer G, Green...

Ngày tải lên: 20/06/2014, 04:20

... 20 719 .7 11 8 01. 5 Total lean mass (DEXA, g) 39458.8 42455 .1 48867.2 43582.5 6038.0 Fat ratio (DEXA, %) 16 .2 32.7 39.5 29.6 12 .6 Total abdominal fat (MRI, cm2) 14 4.0 294.7 414 .6 311 .3 19 1.3 Cholesterol ... variables Predictor Estimate S.E Pr(> |t|) Adjusted R2 Age -2.773 1. 7 51 0 .11 80 -26.283 31. 2 31 0.4030 -0.0043 CD4BL Log10VL -0.607 56.048 0.224 17 .11 0 0.0085 0.0 017 0.0854 0 .12 52 -0. 014 7 negative ... 0.9293 -0. 014 8 LDL/HDL ratio -9.432 5.358 0.0829 0.0299 Waist circumference -1. 128 1. 2 81 0.3 817 -0.0033 Waist/hip ratio Fasting glucose -458.084 -28 .17 1 18 3.0 71 23.307 0. 014 8 0.2 310 0.0 718 0.0067...

Ngày tải lên: 20/06/2014, 08:20

... 2006, 11 7: 11 63-9 26 Bonfield TL, Panuska JR, Konstan MW, Hilliard KA, Hilliard JB, Ghnaim H, Berger M: Inflammatory cytokines in cystic fibrosis lungs Am J Respir Crit Care Med 19 95, 15 2: 211 1-8 ... allowed to differentiate for to weeks, then switched to liquid-liquid interface, (LLI) and treated with either DMSO 1: 1000 (vehicle control) or 20 µM CFTRinh172 [ 21] Drugs were added to both ... 600 fold in the IB3 -1 cells as compared to 350 fold in the S9 cells compared to baseline controls 11 TNF-α and/or IL -1 causes increased activation of AP -1 in CF as compared to β control cells...

Ngày tải lên: 11/08/2014, 03:20

... cells from death J Clin Invest 2006, 11 6:974-983 Zane et al Retrovirology 2 010 , 7 :17 http://www.retrovirology.com/content/7 /1/ 17 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 Zane L, ... CD4 + (33%) and 3 /12 CD8 + (25%) clones In tax positive clones derived from in vitro infection, the HTLV- 1 tax mRNA load ranged from 16 .7 to 474.5 AU (mean ± se of mean 11 4 .1 ± 61. 0) without significant ... 33/36 CD4+ ( 91. 7%) and 17 /19 (89.5%) CD8+ clones In these tax positive clones derived from TSP/HAM, the HTLV- 1 tax mRNA load ranged from 41. 5 to 603475.5 AU (mean ± se of mean 13 9 816 .0 ± 30965)...

Ngày tải lên: 12/08/2014, 23:23

... immunodeficiency virus -1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages Journal of Experimental Medicine 19 94, 17 9 :10 1 -11 3 19 20 21 22 23 24 ... Env, but not Nef contributes to the enhanced replication of the R5, AIDS-associated HIV -1 clone ACH142-*E 11 compared to two pre-AIDS R5 HIV1 clones derived from the same patient [ 61] Previous studies ... supported by an Infectious Diseases Training Grant, T32 A107046, awarded to the University of Virginia 17 18 References 10 11 12 13 14 Kirchhoff F, Easterbrook PJ, Douglas N, Troop M, Greenough TC,...

Ngày tải lên: 13/08/2014, 05:20

... southwestern Japan Int J Cancer 2000, 85: 319 -324 Page 10 of 12 (page number not for citation purposes) Retrovirology 2008, 5:46 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Matsuoka M, Jeang ... type -1 tax expression Am J Pathol 20 01, 15 8:2 219 -2228 Menten P, Wuyts A, Van Damme J: Macrophage inflammatory protein -1 Cytokine Growth Factor Rev 2002, 13 :455-4 81 Sharma V, Lorey SL: Autocrine ... fragment ( -11 20 Bam H1 to +1 Hind III) into the pGL2 basic vector ACH, pcTax, BCRex, HBZ plasmids were obtained from the laboratory of Dr Patrick Green (The Ohio State University) p12, p13 and p30...

Ngày tải lên: 13/08/2014, 05:20

... processes 15 51 2 41, 2, 14 6a1, 15 53 211 ,2, 2 41, 2 15 53 14 6a3 213 2 41, 2,3, 15 53 14 6a1 1, 2, 15 51, 2,3 24 2 41 211 ,2, 2 41, 2, 14 6a3 14 6a1,3 211 , 2 41 243 243, 14 6a1,2, 15 51 1553 211 , 2 41, 15 5 213 15 51 signal ... YOD1 VGLL3 PPM1D CYBB RP 11- 93B10 .1 COL19A1 LOC34 812 0 AFF1 RDX RIT1 USP 31 ARHGEF1 SERTAD2 24 14 6a 2 1 2 1 1 1 1 1 1 1 1 1 3 2 3 1 1 1 1 1 1 1 1 1 3 2 2 2 1 1 2 2 1 1 1 1 Gene ontology (GO) terms ... 5 :10 0 http://www.retrovirology.com/content/5 /1/ 100 16 00 miR- 21 1200 *** 10 00 800 600 400 200 14 00 miR -14 6a 12 00 *** 10 00 800 600 400 200 miR -19 1 200 ns 15 0 10 0 50 miR relative copy no 6800 * 10 00...

Ngày tải lên: 13/08/2014, 05:21

... 5 :10 1 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 protein expression is repressed by miR -15 5, and its restoration inhibits pancreatic tumor development Proc Natl Acad Sci USA 2007, 10 4 :16 170 -16 175 ... Nat Med 2007, 13 :12 41- 1247 Han Y, Siliciano RF: Keeping quiet: microRNAs in HIV -1 latency Nat Med 2007, 13 :11 38 -11 40 http://www.retrovirology.com/content/5 /1/ 1 01 25 26 27 28 29 30 31 32 33 34 35 ... required to test these predictions miR93 miR130b NFkB miR155 miR146a TP53INP1 SMAD5 IRAK6 TRAF1 apoptosis proliferation / transformation immune response Figure targeted1mRNAs: TP53INP1, Smad5...

Ngày tải lên: 13/08/2014, 05:21

... http://www.retrovirology.com/content/5 /1/ 105 1n eo Retrovirology 2008, 5 :10 5 Galectin -1 Tax β-Actin Tax 703 + +/- 0,25 Tax + - Tax M22 + + Tax WT + + + K30 + + + C CEM-T4 Ta x WT eo ph βP r .1 n 0 ,1 WT 0 ,15 Sup T1 Ta x 0,2 ... http://www.retrovirology.com/content/5 /1/ 105 B 10 0 10 0 ,1 NF-κB-Luc κ HTLV- Luc 350 * 300 250 ** 200 15 0 10 0 ** ** 50 ** CEM-T4 Jurkat E6 .1 phβPr.1neo SRE-Luc Tax M22 Sup T1 Tax WT D Normalized luciferase ... βP r .1 ne o B Relative Galectin -1 mRNA expression phβPr .1 neo NF-κB CREB SRF - Galectin -1 0,05 β-Actin phΒ Tax7 03 Tax TaxM22 TaxWT Figure of Analysis galectin -1 expression in WT and mutant Tax- expressing...

Ngày tải lên: 13/08/2014, 05:21

... 3606) Page 12 of 13 (page number not for citation purposes) Retrovirology 2007, 4:92 References 10 11 12 13 14 15 16 17 18 19 20 21 Jeang KT: Retrovirology highlights a quarter century of HTLV- I ... activity [11 -13 ] Thus, through its interaction with CREB-2 (also called ATF-4), HBZ inhibits Tax- mediated proviral transcription from the HTLV- 1 promoter within the viral LTR [10 ,14 -16 ] Tax, a viral ... Matsumoto J, Ohshima T, Isono O, Shimotohno K: HTLV- 1 HBZ suppresses AP -1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein Oncogene 2005, 24 :10 01- 1 010 Thebault...

Ngày tải lên: 13/08/2014, 05:22