antiproliferative effects of carotenoids on cancer cells

... associations have centered on the caffeine content of coffee [26] In fact, caffeine has a variety of pharmacological actions and cellular responses Coffee is one of the most widely consumed psychoactive ... considered significant http://www.josr-online.com/content/1/1/7 DNA degradation analysis For the DNA fragmentation, a concentration of × 106 cells/ 100 μl was added to 90 mm disc From day one of ... the size of 200 – 1000 bp (Fig 5) stimulation of the central nervous system and cardiac muscle, increased urinary output, and relaxation of smooth muscle [23] The effects of coffee on bone metabolism...

Ngày tải lên: 20/06/2014, 00:20

... 5.5 ± 0.8) Stimulation with a low concentration of CCL20 (10 ng/ml) decreased the proliferation of anti-IgMstimulated peripheral blood B cells In contrast, a high concentration of CCL21 (1000 ng/ml) ... analyzed the effects the chemokines on migration of peripheral blood B cells Each of the four chemokines induced migration of both CD27- and CD27+ B cells (Figure 3a) However, the migration induced ... Comparison of the migratory effects of the chemokines on peripheral blood CD27- and CD27+ B cells in each individual showed that for each of the chemokines, the chemotactic response of CD27+ B cells...

Ngày tải lên: 09/08/2014, 14:22

... TK, Kung HF, Yuen MF, Chan AO, Wong BC: Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1 Cancer Lett 2008, 260:62-71 29 ... up-regulated the expression of SSTR1-5, and that apoptosis was activated mainly via the induced expressions of SSTR2 and SSTR3 The effects of somatostatin on the prostate cancer cells may be mediated ... effect of XAF1 combination with these factors on inhibition of tumour growth in vivo and demonstrated that XAF1 can hinder tumour progression and promote outright regression in combination with...

Ngày tải lên: 10/08/2014, 10:20

... fluorophore on the reducing ter- Page of 11 (page number not for citation purposes) Journal of Hematology & Oncology 2009, 2:25 http://www.jhoonline.org/content/2/1/25 β-glucan1is one of the key components ... granulocytes, monocytes or macrophages via the complement receptor (CR)-3 The immune response will then be turned on, one of the actions is the phagocytosis of the monoclonal antibody tagged tumor cells ... peripheral blood mononuclear cells proliferation [46] It can also enhance phenotypic and functional maturation of monocyte derived dendritic cells with significant IL-12 and IL10 production Similar...

Ngày tải lên: 10/08/2014, 22:20

... finding that tendons appear to contain subpopulations of cells; one subpopulation with apparently normal metabolic activity and a second subpopulation of cells with low levels of mitochondrial enzymes ... investigated the effects of NSAIDs on both primary tenocytes and secondary and tertiary subcultures of the cells Methods Isolation and culture of tendon derived cells: Tendon derived cells (TDC) were ... of acute inflammatory cells in chronic tendonitis, NSAIDs are used com- Figure varying concentrations for of rat tail tendon derived cells at blue obtained after culture and days Comparison of...

Ngày tải lên: 20/06/2014, 01:20

... effects of an acidic polysaccharide of Panax ginseng on bone marrow cells J Vet Sci 2007, 8, 39-44 10 Kim MH, Joo HG Immunostimulatory effects of fucoidan on bone marrow-derived dendritic cells ... Radioprotective effects of fucoidan 363 Fig Surface marker expression was up-regulated on bone marrow cells (A) Numbers indicate the percentage of high expressed cells (M1) compared to that of fluorescence ... cytokine production of bone marrow cells (BMCs) The supernatants of BMCs were collected and ELISA was performed to quantify cytokine concentrations N/D: non-detectable level of cytokine Asterisks...

Ngày tải lên: 07/08/2014, 23:22

... proliferation T cells were resuspended in PBS 5% FCS at a concentration of to × 10 cells/ ml and incubated with CFSE (final concentration of 50 μM) for minutes at room temperature Cells were washed ... proliferation of CD4+ T cells was analyzed by detection of CFSE dilution by flow cytometry The percentage inhibition (100 × [(percentage of proliferating CD4+ cells not treated with MSCs – percentage of ... isolation and characterization of MSCs; MSC stimulation, quantitative PCR, and Bio-Plex; CIA induction and evaluation; humoral and cellular responses; analysis of T-cell proliferation; design of...

Ngày tải lên: 12/08/2014, 11:23

... (MXF) on spontaneous IL-8 release from hu-BE,*p < 0.05 vs control levofloxacin at concentrations of 1, 4, and mg/l Incubation with moxifloxacin led to a concentration dependent reduction of IL-8 ... accumulation of macrolides and quinolones in lung cells and in alveolar macrophages a targeted modulation of the inflammatory reaction could be of additional therapeutic benefit by attenuation of the ... cells MXF decreases NO production and NF-κB-activation [5] Our study demonstrates anti-inflammatory effects of quinolones in a human ex vivo model of primary bronchial epithelial cells The concentrations...

Ngày tải lên: 12/08/2014, 14:20

... exerted protective effects on the endothelial cell layer of the pulmonary vessels but the detection of a low percentage of donor cells does not give conviction about the mechanisms of this beneficial ... statistically significant Results Effects of bone marrow-derived cells on monocrotalineinduced pulmonary hypertension (PH) PH developed within 15 days of MCTp injection, as shown by a sustained increase ... Detection of GFP-positive bone marrow-derived cells in lungs from recipient mice Immunohistochemical analysis of lung sections from control eGFP-positive mice revealed strong immunostain- Page of...

Ngày tải lên: 12/08/2014, 15:20

... infected cells Addition of flavopiridol at a concentration of 10 nM antagonized the effects of prostratin, resulting in 70% or greater reduction Page of 14 (page number not for citation purposes) ... NF-κB and contribute to stimulation of elongation by this transcription factor [43] Thus, prostratin stimulation of NF-κB through the up-regulation of Cyclin T1/P-TEFb is also likely to contribute ... resting CD4+ T cells, only low levels of transcriptional elongation are needed and the levels of PTEFb are low Upon T cell activation, there is an increase in the overall level of P-TEFb to fulfill...

Ngày tải lên: 13/08/2014, 09:20

... and the promotion of monocyte adhesion 39 3.4 CD137 expression on cancer cells and protection against drug-mediated cytotoxicity 46 3.5 Functional characterisation of MCF7/hCD137 ... variants .50 3.5.1 Effect of CD137 on IL-8 secretion by MM5 and THP-1 cells 51 3.5.2 Effect of CD137 on T cell proliferation .55 3.5.3 Quantification of CD137 present on MCF7 variants by live ... ROLE OF CD137 AS A NEOANTIGEN ON CANCER IIIIICELLS As mentioned in Section 1.1, CD137 is expressed by certain cancer cell types In particular, CD137 was present on B cells in all the cases of CLL...

Ngày tải lên: 03/10/2015, 11:37

... and additional analgesic consumption These findings may be related to the antiinflammatory effects of flurbiprofen VAS scoring is a simple and often used method for evaluating variations in pain ... postoperative complications and mortality (18) Many reports confirm our finding that IL-6 concentration in the control group on postoperative first day after pulmonary resection over 100 pg/ml (2,19,20) ... the study because of severe side effects (Table 2) Figure Changes in serum concentration of CRP before and after thoracotomy in the study groups Table Side effects and complications in the postoperative...

Ngày tải lên: 25/10/2012, 11:10

... communication in the modulation of vasomotor tone Circ Res 1996; 79(4): 631-46 Yeh HI, Lupu F, Dupont E, Severs NJ Upregulation of connexin43 gap junctions between smooth muscle cells after balloon catheter ... junctional communication and thus the proliferation of vascular smooth muscle cells Intima of artery has mutual communication between cells and between cells and their environment These cells in the vessel ... muscle cells changed from contraction type to the conversion type in vitro (8) Cx43 is required for the formation of the atherosclerotic plaque Previous study demonstrated that rats lack of Cx43...

Ngày tải lên: 26/10/2012, 09:39

... revealed a consistent pattern of the effect of smoking on risk of cancer deaths TABLE Characteristics of cases and two control groups: Population-based case-control study of smoking on risk of cancer ... methodological areas of control selection, it is widely accepted that the inclusion of multiple control groups selected by different criteria is preferable to only one control group.20-23 Multiple control ... assess more relationships between one or more exposures and various causes of death at one time, and use of a single control group for more than one case series can lead to saving of money and time;11-12...

Ngày tải lên: 26/10/2012, 09:48

... Regulation of mineralization Regulation of bone turnover Glucose regulation Regulation of collagen fibrillogenesis Regulation of bone formation Osteoclast recruitment Inhibition of mineralization ... the inhibition of bone formation (confirmed by bone histomorphometry) and lower concentrations of bone formation markers (especially OC) [60, 61] By contrast, data on bone resorption markers levels ... hormones are major determinants of bone turnover in older men Low concentration of the bioavailable fraction of 17-estradiol is strongly associated with higher levels of the markers of bone...

Ngày tải lên: 14/02/2014, 21:20

... compilation ª 2006 FEBS N Bluthgen et al ¨ Effects of sequestration the Michaelis–Menten constant of the kinase The concentration of the complex [TK] approaches the total concentration of the kinase ... expressed the response of the active fraction to a change of the kinase concentration as a function of the concentrations of the two forms ([T] and [T*]) and the elasticities of the enzymes by ... activity of the kinase (G–I) (A) Contour plot of the response T coefficient RKTÃ as function of the total concentration of the phosphatase and the kinase (normalized to the phosphatase concentration)...

Ngày tải lên: 19/02/2014, 07:20

... end of continuous treatment (Figs and 7) Most of the cells showed polyploidy and multinucleation instead of displaying signs of ÔclassicalÕ apoptosis as nuclear condensation or DNA fragmentation ... is a strong inhibitor of Sp1-activated transcription in vitro, at nanomolar range concentrations [10] The observation of WP631 accumulation inside the nuclei is consistent with the location prevalently ... levels of p53 in cells continuously treated with WP631 decreased, which was consistent with the suppression of the arrest in G2/M, the production of polyploidy, and the final death, independent of...

Ngày tải lên: 20/02/2014, 23:20

... combination of text and visuals elicits beneficial effects in terms of comprehension of the material Visuals not only offer additional contextual information to facilitate comprehension, perhaps ... on the translation task because the inclusion of pictures with the text provided readers with two sources of information instead of one The positive effect of pictures on reading comprehension ... offered additional contextual information to the students, confirming the value of DCT Furthermore, Hall, Bailey, and Tillman [31] conducted a study to examine the effects of illustrations on reading...

Ngày tải lên: 05/03/2014, 12:20

... mergers In contrast, there have been no academic studies of the profit efficiency effects of mergers and very little research on the market power effects of bank mergers Studies of the effects of mergers ... studies of profit efficiency effects and very few studies of the market power effects of bank mergers Prior studies of bank profitability ratios, such as return on assets or return on equity, may confound ... profits may confound the effects of I’Studies of the effects of market power on bank prices have generally found that banks that operate in more concentrated local markets pay lower rates on...

Ngày tải lên: 06/03/2014, 08:21