Báo cáo y học: "Analysis of mammalian gene batteries reveals both stable ancestral cores and highly dynamic regulatory sequences" pot

... R172 Research Analysis of mammalian gene batteries reveals both stable ancestral cores and highly dynamic regulatory sequences Laurence Ettwiller *‡ , Aidan Budd † , François Spitz * and Joachim ... evolution<p>Analysis of the evolutionary dynamics of target gene batteries controlled by 16 different transcription factors reveals stable ancestra...

Ngày tải lên: 14/08/2014, 21:20

... the CDR of V H and V L gene rearrangements of B cells obtained by minor salivary gland biopsies from two patients with SS [6]. Detailed analyses of the frequency of occurrence and mutations of the highly ... SS and of normal donors. Table 2 Mutational frequency of Vκ gene rearrangements of B cells from the peripheral blood and from the parotid gland of a patien...

Ngày tải lên: 09/08/2014, 03:24

... cytotoxic granule and cytokine release), antigen presen- tation and antibody-dependent cellular cytotoxicity [6]. Con- versely, FcγRIIb contains an inhibitory motif in the cytoplasmic tail and ... the collection of clinical data and the recruitment of patients into the study. DS, JR and VK undertook some of the genotyping assays on DNA prepared in the laboratory of EAJ and...

Ngày tải lên: 09/08/2014, 07:20

... trans-activation of the CMV promoter by cellular and viral gene products [51], and most importantly, also the type and dynamic range of analysis system utilized for quantification. Enhancement values of > ... strong and specific deliv- ery of therapeutic genes is one of the main goals of can- cer therapy, it may be of importance for the general usage of the bina...

Ngày tải lên: 12/08/2014, 04:20

... pulmo- nary fibrosis (IPF) is characterized by a predominance of gene expression for Th2-type regulatory cytokines. This pattern is associated with high levels of IL-4 and IL-5 and a paucity of IFN-γ ... required. Results Tables 1 and 2 summarize the genotype, and allele fre- quencies for IL-12 p40 and IFN-γ gene polymorphisms in patients with IPF and controls. Both...

Ngày tải lên: 13/08/2014, 13:20

... Intuitively, the synthesis or degrada- tion of some mRNAs in G1/S phase and G2/M may be dif- ferentially affected by thy-thy and thy-noc arrests, respectively. Measurements of the intensities of gene ... increased. One often neglected but important factor in interpreting and analyzing cell cycle related gene expression data is the quality of synchrony of the cell culture....

Ngày tải lên: 13/08/2014, 23:20

... degradation, where genes closer to the 3' Table 2 Classification of genes by predicted regulatory sites and fraction of OIGs and NOIGs that fall into each gene type Type number Predicted ... brings on a general response to starvation, osmotic, oxidative, and heat stresses [39]. Streptomycetes inhabit highly diverse and dynamic soil and aquatic environments and, as...

Ngày tải lên: 14/08/2014, 16:21

... rudi- mentary. Our analysis suggests that tumors in group 1 recapitulate an embryonic phenotype: they express early developmental and stem cell genes, suppress genes character- istic of mature tissues and ... upregulated genes and high values of i (late development) for downregulated genes. Perhaps unexpectedly, the specificity of upregulated lung cancer genes for early developmen...

Ngày tải lên: 14/08/2014, 20:22

... understanding of how imprinted regions have evolved and to comprehensively test the host defence hypothesis, we have examined, on a genome scale, the conservation of synteny and accumulation of repeats ... Marilyn B Renfree * Addresses: * Department of Zoology, The University of Melbourne, Melbourne, Victoria 3010, Australia. † Department of Molecular and Cellular Biology...

Ngày tải lên: 14/08/2014, 21:20

... that glutamine may regulate expression of the same gene via different pathways as a function of cell type and pathophysiological conditions. In addition to its effect on the ASS gene, glycosylation of Sp1 ... rat mammary tumours, the dietary amino acid also coun- teracted the proliferative effect of c-myc by reducing its phosphorylation and mRNA level and by stimulat- ing pho...

Ngày tải lên: 07/03/2014, 00:20