Báo cáo y học: "Mice get their annual check-up" pdf

... of the egg cylin- der and apparently never shifts to the long axis. Could Wnt3 be a causative factor for the shift? Coming to your senses Have you ever wondered why after you brush your teeth ... this embryo shape change? Jeff Barrow (Brigham Young University, Salt Lake City, USA) supplied evidence for a candidate gene, Wnt3, that might play an important part. Wnt3 is normally expressed ......

Ngày tải lên: 14/08/2014, 14:21

... recently brought together researchers from around the world who use the chicken as a model system, and was designed to give as many young researchers as possible the opportunity to communicate their ... later, in the interdigital areas of 5-day-old embryos, the interdigital tissue did not regress, leading to “webbed” digits (syndactyly). Erg1 is thus a key player in limb induction, outgrowt...

Ngày tải lên: 14/08/2014, 07:21

... been reported to play a key role in chestnut allergy. Adverse reactions to chestnuts are usually associated with allergy to latex within the latex-fr uit syndrome that is mainly caused by class I chitinases ... enzymes - X Protein kinases - X Group 5 ragweed allergens - X Papain-like cysteine proteases - X 60S acidic ribosomal proteins - X Kunitz-type trypsin inhibitors - X Glycoside hydrolas...

Ngày tải lên: 08/08/2014, 21:20

... have as yet described all the man- ifestations necessary to be considered a spontaneous model of relapsing polychondritis – which is characterized not only by polyarthritis, but also by involvement ... phenotype, more closely mirroring human RP than induced polychondritis. This model occurs in the absence of overt stimulation by an exogenous antigen such as CII, or adju- vant, or by artificia...

Ngày tải lên: 09/08/2014, 08:22

... disulfide bonds formed by the six cysteine residues (Figs 1 and 6). Thus in BACE2, the three disulfide bonds are assumed to be Cys233–Cys433, Cys292–Cys457, and Cys344–Cys393. Such a disulfide bond ... stability, the presence/absence of the C-tail apparently affects the substrate specificity of the enzyme. Indirectly, the rigidity associated with the C-tail, particularly the two disulfide bonds, m...

Ngày tải lên: 17/03/2014, 10:20

... severity in the airways of asthmatic patients. 58 Moreover, neu- trophils and their products are strongly associ- ated with early pathogenesis of COPD. 59 Further analysis of the signalling pathways ... carried out by kinases, which are themselves frequently acti- vated by phosphorylation by upstream molecules. This specifically involves the attachment of a phosphate molecule, donated by in...

Ngày tải lên: 08/08/2014, 21:20

... antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 1999, 189:1639-1648. 7. Lipsky PE: Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. ... with B lymphocyte depletion. Ann Rheum Dis 2002, 61:883-888. 17. Leandro MJ, Edwards JC, Cambridge G, Ehrenstein MR, Isenberg DA: An open study of B lymphocyte depletion in systemic lupus erythe...

Ngày tải lên: 09/08/2014, 01:21

... permeability, leukocyte recruitment and activation Cysteinyl leukotrienes Vascular permeability, immunomodulatory (LTC 4 ) Cytokines/chemokines IL-1 Leukocyte recruitment, fibroblast/chondrocyte activation, ... Interestingly, whereas normal human synovium contains mainly mast cells of the so-called ‘connective tissue’ phenotype, expressing both tryptase and chymase in their granules (MC TC...

Ngày tải lên: 09/08/2014, 01:24

... from both academia and industry, were brought together to discuss plant pathogen genomics at the British Society for Plant Pathology’s annual Presidential meeting, hosted by this year’s president, John ... Pseudomonas syringae pv. tomato DC3000 of specific effectors of the pathogen’s type III secretion system; this effectively converts a virulent pathogen to avirulence. John Mansfield (Impe...

Ngày tải lên: 09/08/2014, 20:21

... with surprising frequency, a method that can rapidly and reliably link human genes to non-obviously related phenotypes in model systems offers the prospect of radically accelerating the rate ... disorders and their asso- ciated genes [7]. Among their findings was a large subnet formed by 516 of the 1,284 disorders studied, clearly showing many-to-many relationships between pheno- type...

Ngày tải lên: 09/08/2014, 20:21