Báo cáo y học: "Social regulation of gene expression in human leukocytes" pps

... microarray analysis identified 209 genes that were differentially expressed in circulating leukocytes from 14 high- versus low-lonely individuals, including up -regulation of genes involved in immune ... down -regulation of genes supporting mature B lymphocyte function and type I interferon response. Promoter-based bioinformatic analyses showed under -expression of genes bearing...

Ngày tải lên: 14/08/2014, 08:20

... may be differently regulated by inflammatory cytokines, suggesting a dynamic interplay that might have a potential role in airway inflammation. Background Allergic asthma is characterised by ... airway hyperreactivity in animal studies [12-14], they may have distinct roles in allergen-dependent airway obstruction [24]. Hence, NGF may play a role in the early airway response (EAR) in...

Ngày tải lên: 12/08/2014, 16:20

... may alter gene expression patterns in postmortem human brains. Study of expression levels of 14 genes in human brain autopsy and biopsy samples found significant change in one of the genes, indicating ... translated to functional proteins, up -regulation of genes involved in ubiq- uitin-dependent protein catabolism may lead to increased degradation of proteins in...

Ngày tải lên: 14/08/2014, 16:20

... cap-independent, a property previously described only for cellular mRNAs. RNA-binding proteins have key roles in the regulation of nearly every aspect of gene expression. They often display a modular architecture, ... showed that binding of ZBP1 probably inhibits translation by inter- fering with the formation of the 80S ribosome during initia- tion. Two different pathways for...

Ngày tải lên: 14/08/2014, 14:21

... [18]. The microarray assay used (Panorama Cytokine Gene Array membranes; Sigma Genosys, Inc) included 375 genes enriched in cytokines, chemokines, cell surface 286 ably derive from studies of tissue samples ... among the IFN-induced genes overexpressed in the JDM muscle samples. Increased expression of several genes, including G1P3 (encoding IFN-induced 6-16) and CDKN1A (p21 cycli...

Ngày tải lên: 09/08/2014, 01:23

... farthest in describing the anatomy of gene expression and compares data from numbers of individual animals using different methods to assay gene expression. However, the number of genes covered remains ... project mapping gene expression in the mouse brain is the GenePaint atlas [10], a large-scale European effort led by Gregor Eichele at the Max-Planck-Institute of Bi...

Ngày tải lên: 14/08/2014, 07:21

... Models including the exon 6 indel were clearly inferior and are not shown, given the lack of any previous evidence of the involvement of the exon 6 indel in IRF5 cis -regulation. Each of the remain- ing ... available in the asthma collection of LCLs. Table 1 Expression profiling studies in lymphoblastoid cell lines whose IRF5 data have been analysed a Study Number of LCLs...

Ngày tải lên: 12/08/2014, 15:23

... properly cited. The rarity of gene shuffling in conserved genes<p>The incidence of gene shuffling is estimated in conserved genes in 10 organisms from the three domains of life. Successful gene ... histidinol dehydrogenase) to produce the budding yeast his4 gene, which is involved in histidine biosynthesis. The budding yeast gene appears to combine the functions...

Ngày tải lên: 14/08/2014, 14:21

... highly conserved proteins, such as ribosomal pro- teins, or genes involved in conserved processes, such as bio- synthesis pathways or photosynthesis, to very quickly, for instance genes involved in ... implemented in the R package 'prada' [69], by binning the data (in 100 bins) in both directions. The intensity of blue represents the amount of points in the bin, as d...

Ngày tải lên: 14/08/2014, 16:21

... and heavy chain binding protein, both of which are found in early RA and pre-disease sera [29]. Antibody and T-cell reponses to heavy chain binding protein have been identified both in patients ... play a key role in the pathogenesis of inflammatory arthritis. In addition to autoantibody production, B cells efficiently present antigen to T cells, produce soluble factors, including...

Ngày tải lên: 09/08/2014, 10:20