Báo cáo y học: "A new weapon against an old target" docx

... was strongly superior to those of MTX and as well the TNF-inhibitor etanercept. Most interestingly, EC0746 was markedly safer than native AMT, with a 40-fold diff erence in toxicity, which is ... 42:1609-1616. 6. Feldmann M, Brennan FM, Maini R: Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 1996, 14:397-440. 7. Reiss AB, Carsons SE, Anwar K, Rao S, Edelman SD, Zhang H, Fernan...

Ngày tải lên: 12/08/2014, 17:22

... SOCS-3. Peptide K d (l M ) pY343 > 30 pY401 9.5 ± 0.12 pY429pY431 1.1 ± 0.03 F429pY431 4.6 ± 0.02 pY429F431 4.9 ± 0.02 Y4 2 9Y4 31 ND pY443 ND pY461pY464 ND Y4 61pY464 ND pY46 1Y4 64 ND pY479 ND Ó FEBS 2002 ... Subse- quently, precipitated SOCS-3 was analyzed by Western blotting (Fig. 4). SOCS-3 was found to specifically interact with the tyrosine motifs pY401 and pY429pY431. pY429pY431 w...

Ngày tải lên: 24/03/2014, 00:21

... separated by SDS/PAGE, and analyzed by immunoblotting with anti-(SHP-1) Ig or anti-(SHP-2) Ig. SHP-1 and SHP-2 bind directly to Y6 67 ITIM. Biotinylated tyrosine phosphorylated siglec-10 Y6 67 ITIM peptide ... for phosphorylation), GST–cyto -Y5 97F (Y! F mutation at the 597 position), GST– cyto -Y6 41F (Y! F mutation at the 641 position), GST– cyto -Y6 67F (Y !F mutation at the 667 positio...

Ngày tải lên: 24/03/2014, 04:21

... the tryptophan tryptophyl- quinone (TTQ)-dependent amine oxidases methylamine dehydrogenase (MADH) and aromatic amine dehydroge- nase (AADH), and also the flavoenzymes trimethylamine dehydrogenase ... H-tunneling by a vibrationally assisted mechan- ism, although a Boltzman analysis suggests a very small population in anything other than the vibrational ground state. An alternative explanatio...

Ngày tải lên: 31/03/2014, 23:20

... statistical analysis, editing, and typing of the manuscript. IIS performed the KKS assays and, together with RAP, purified the antibody. RAP also partic- ipated in the statistical analysis, editing ... 9:446-452. 43. Uknis AB, DeLa Cadena RA, Janardham R, Sartor RB, Whalley ET, Colman RW: Bradykinin receptor antagonists type 2 attenuate the inflammatory changes in peptidoglycan-induced acute...

Ngày tải lên: 09/08/2014, 06:22

... antibodies [6], antifilaggrin antibodies [7], anti- cyclic citrullinated peptide (anti-CCP) antibodies [8] and anti- deiminated human fibrinogen autoantibodies (AhFibA) [9-11]. ACPAs may be detected ... plat- form for Clinical research and Analysis in Epidemiology & Public Health Midi-Pyrenees (TIERSMIP). References 1. El-Gabalawy HS, Duray P, Goldbach-Mansky R: Evaluating patients with...

Ngày tải lên: 09/08/2014, 10:20

... the human body. Lack of synchrony between the mas- ter clock and the peripheral clocks can lead to asynchronies within cells (e.g., cell cycle) and between organ systems (e.g., liver and pancreas). ... simultaneously record- ing light-dark and activity-rest data in humans. Signifi- cantly, these data reveal relationships between circadian light-dark patterns actually experienced by day-shift...

Ngày tải lên: 10/08/2014, 09:20

... Coronary artery aneurysm: a review. Prog Cardiovasc Dis 1997, 40:77-84. 4. Gurtu R, Uemura H, Tsuda E, Dubrey SW: Giant coronary artery aneurysms and myocardial infarction: aetiology and management. ... 4). Conclusions Coronary artery aneurysms may be complicated by thrombosis and rupture. The optimal treatment options of coronary aneurysms are still largely debated. They include anticoagulat...

Ngày tải lên: 11/08/2014, 03:21

... largest coronary vessel by 1.5 to 2 times. Coronary artery aneurysms are typically diagnosed by coronary angiography. The prognosis of coronary artery aneurysm is not well known and the management ... 68-year -old Italian-Caucasian man presented to our hospital with angina. Coronary angiography revealed a large coronary aneurysm of the right coronary artery, which was successfully treated by...

Ngày tải lên: 11/08/2014, 07:20

... USA Email: Ryan E Campbell-Anson - recampbe@mdanderson.org; Diane Kentor - dhkentor@mdanderson.org; Yi J Wang - yjwang@mdanderson.org; Kathryn M Bushnell - kbushne@mdanderson.org; Yufeng Li - yufenli@mdanderson.org; ... technology Ryan E Campbell-Anson 1 , Diane Kentor 1 , Yi J Wang 1 , Kathryn M Bushnell 1 , Yufeng Li 1 , Luis M Vence 1 and Laszlo G Radvanyi* 1,2 Address: 1 Department of...

Ngày tải lên: 11/08/2014, 10:23