Báo cáo khoa học: " Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines" pot

... [3], loratadine alone results in Chk1 activation leading to an increase in the percen- tage of cells in the G2/M phase of the cell cycle. Since the G2/M phase of the cell cycle is one of the most ... determined by dividing the density of the released DNA band by the density of the total DNA in the l ane (the released DNA band plus the unre...

Ngày tải lên: 09/08/2014, 10:20

... the effects of the neighboring chromatin (e.g. heterochro- matinization) if the reporter is flanked by two of them. The apparent function of the boundaries within BX-C is to separate neighboring ... [11]. However, these effects are observed only if at least one copy of them is present in a transgenic insert, and the significance of this high affinity pairing in the...

Ngày tải lên: 20/02/2014, 01:20

... suggesting that the two adenine nucleotides may work in synergy to maintain the resting tone of the bladder. In conclusion, extracellular cADPR enhances the spontaneous release of ATP in the bladder ... preparation. Of particular importance is the finding that exogenous cADPR failed to increase the spontaneous release of ATP in the absence of CD38. In othe...

Ngày tải lên: 05/03/2014, 23:20

... (GUMP, GIST, GANT, and now GIPACT). Implications of c-kit in genesis, and yet another of many emerging roles of the interstitial cell of Cajal in the pathogenesis of gastrointestinal disease. Adv ... expression of the c-kit receptor (CD117), as is their cell of origin, the intersti- tial cell of Cajal [2]. Detection of the c-kit protein in tumour ce...

Ngày tải lên: 09/08/2014, 01:24

... the C-terminal C 5 -domain, catalyzing the intramolecular nucleophilic attack of the L-hOrn 3 a-amino group onto l-haOrn 4 . Taking into account that the synthetases involved in the bio- synthesis ... enterobactin and coelichelin [6,7]. The C-terminal adenylation domain A 4 again is predicted to activate l-arginine, displaying 60% identity to the characterized A-domain of...

Ngày tải lên: 16/02/2014, 09:20

... Le a determinant. As the C 3a ion is at m/z 690, this excludes the possibility of the other Fuc being at the Gal next to the subterminal GlcNAc. The position of the second Fuc 3-linked to the internal ... function. One of the early demonstrations of the role of carbo- hydrates in recognition was binding of the in uenza virus to red blood cells via sialic a...

Ngày tải lên: 19/02/2014, 12:20

... for example, in order to save energy and protein synthesizing capa- city. This would be preferable to placing all the genes involved in the pathway in the same operon; the cell can then respond ... expres- sion of the las operon around the normal level led to little change in the production pattern. By coregulating PK and LDH cells can maintain homolactic ferment...

Ngày tải lên: 19/02/2014, 17:20

... including: biosynthesis of colla- gen and other hydroxyproline ⁄ hydroxylysine-containing proteins ⁄ peptides; synthesis of secondary metabolites, hormones and cytokines [1]; oxidative protein ... protein band, thus pointing to the absence of a covalently bound flavin moiety in the recombinant product. Moreover, as in the case of the plant l-galactono-1,4-lactone dehydr...

Ngày tải lên: 07/03/2014, 12:20

... concentra- tions of the metal ion [45]. The addition of E64, a syn- thetic inhibitor of calpain, did not modify the intensity of the signal observed in the presence of Ca 2+ alone. The increase in the mAb-binding ... by evaluating the intensity of the light signal generated by the binding of mAb 56.3. To perform these investigations, the two preferentia...

Ngày tải lên: 07/03/2014, 12:20

... phosphatidylinositol-3-kinase, as well as activating tyrosine phosphorylation. An increase in intracellular levels of cAMP [6,7] and the involvement of kinases, such as protein kinase C (PKC) and mito- gen ... regions including talin, vinculin and integrins (focal adhesions). Within these regions, several components of the cytoskeleton are concentra- ted, together with a num...

Ngày tải lên: 07/03/2014, 16:20