... cysteinyl residue in the PIII disintegrin-like domain, residing in what is called the RGD loop in disintegrin domains (Fig. 6; residue 468, VAP1 num- bering). The potent integrin-binding inhibitor ... venom. Interesting structural features in disintegrin, disintegrin-like and cysteine-rich domains There are several interesting structural features associ- ated with SVMP disintegrin, di...
Ngày tải lên: 18/02/2014, 18:20
... Pleckstrin (PH) homology domain in the N-terminal region, all the other PLD isoenzymes possess a calcium- and phos- pholipid-binding domain (C2 domain) at the N-ter- minus [5]. From white cabbage, ... present in all members of the PLD superfamily. However, there is low similar- ity in the remaining parts of the molecules. Most mam- malian PLDs contain a PX and a PH domain instead of the...
Ngày tải lên: 19/02/2014, 02:20
Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx
... between arginine and agmatine. Agmatine, which results from decarboxylation of arginine by arginine decarboxylase, is a metabolic intermediate in the biosynthesis of putrescine and higher polyamines ... agmatine in E. coli agmatinase and l-arginine in B. caldovelox arginase [37], indicating that the substrate specificity of these enzymes rely mainly in substituents at C-a. This has bee...
Ngày tải lên: 20/02/2014, 02:21
Tài liệu Báo cáo khoa học: "Insights into Non-projectivity in Hindi" docx
... 2008b) can be extended to incorporate graph properties discussed in section 3 as constraints. Further, linguistic insights into non-projectivity can be used in parsing to identify when to generate the ... parsers for Hindi and other Indian languages. Hindi, being a morphologically rich, flex- ible word order language, brings chal- lenges such as handling non-projectivity in parsing...
Ngày tải lên: 20/02/2014, 09:20
Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
... also IPU. The results indicated that IPU is an anomer-inverting enzyme (Fig. 5A). In the case of inverting enzymes, a single displacement mechanism has been proposed [6,17,19–21]. In this mech- anism, ... Cloning of the Penicillium minioluteum gene encoding dextranase and i ts expression in Pichia pastoris. Yeast 12 , 1187–1200. 4426 H. Akeboshi et al. (Eur. J. Biochem. 271) Ó FEBS 2004...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
... under investigation in our laboratory. In any case, despite the structural differences between agmatinase and arginase, agmatine and arginine were fixed in essentially the same position in the ... urea [1]. Agmatine, which results from decarboxylation of arginine by arginine decarboxylase [2], is a metabolic intermediate in the biosynthesis of putrescine and higher polyamines [1] and...
Ngày tải lên: 21/02/2014, 01:21
Tài liệu Báo cáo khoa học: "Parsing into Discourse Object Descriptions" pptx
... able to recognize information that it lacks for booking a meeting by comparing the information it has with a definition for a booking command. Having done this it may take the initiative and ... how interactions begin. Knowledge about interactions is stored in the object type definition for interactions. This definition basically provides a grammar of constraints on possible interact...
Ngày tải lên: 22/02/2014, 10:20
Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc
... GS staining (B3), and 4¢,6-diamidino-2-phenylindole (DAPI) staining (B4), respectively. (B5-8) High magnification images of the boxed area in (B4) showing RPE65c staining (B5), GS staining (B6), ... recycling of 11cRAL through a process involving multiple enzymes and retinoid-binding pro- teins between photoreceptors and retinal pigment epi- thelium (RPE); it is essential for maintaining nor...
Ngày tải lên: 14/02/2014, 14:20
Tài liệu Báo cáo khoa học: Applications and trends in systems biology in biochemistry docx
... protein kinase; MCF, macrophare chemotactic factor; MCIP, modulatory calcineurin-interact- ing protein; MDCK, Madin Darby canine kidney; MEF, mouse embryonic fibroblast; MEK, MAP kinase/ERK kinase; ... glycogen synthase) is insufficient to accurately explain insulin-stimulated changes in the concentration of intracellular species and partitioning of glucose disposal in skeletal muscle. Insu...
Ngày tải lên: 14/02/2014, 14:20
Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... mutation in the BTK PH domain; arginine 28 is in dark blue, encircled in red. Bottom left: SH2 domain. Right: kinase domain. The mutated residues are indicated in yellow, a-helices are in cyan, ... signaling proteins carrying domains also found in BTK. In 2009, an inactivating mutation in the ITK gene was shown to cause susceptibility to lethal Epstein–Barr virus infec- tion....
Ngày tải lên: 14/02/2014, 18:20