Tài liệu Báo cáo khoa học: Gas6 and protein S Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily pptx

... through their binding to and activa- tion of the receptor tyrosine kinases Axl, Sky and Mer. Furthermore, a hallmark of the Gas6 Axl system is the unique ability of Gas6 and pro- tein S to tether their ... Gas6 and protein S for Axl, Sky and Mer RTKs within and across different species (both rat Gas6 and human protein S were shown to stimulate rab...

Ngày tải lên: 19/02/2014, 05:20

... (PH) and SH2] or phosphorylated insulin receptor- interacting region (PIR) [6] and inhibits the tyrosine kinase activity of the IR [7]. On the basis of the crystal structure of the tyrosine kinase ... enzymatic activity and share a common multidomain structure. These adaptors bind to several receptor tyrosine kinases and signaling proteins, and are involved in...

Ngày tải lên: 18/02/2014, 18:20

... product was observed in all the Xenopus tissues tested except the liver and the ventral skin. The amount of the xTRH receptor mRNAs in these tissues was assayed using a set of primers corresponding ... potential sites for N-linked glycosylation in its N-terminus, at the conserved positions (3 and 10), while xTRHR2 had these sites at positions 3 and 12. The glycosylatio...

Ngày tải lên: 21/02/2014, 03:20

... 80% of the corpus (979,767 words) is taken as the training set, used for estimating the various co-occurrence probabilities, 10% of the corpus (133,814 words) is taken as the testing set, used to ... of information theory and draws a series of conclusion on their predictive powers for syntactic structures. 2 The probabilistic evaluation model for statistical syntactic pars...

Ngày tải lên: 20/02/2014, 18:20

... it is therefore systems biology). This latter point necessitates the definition of the term ‘systems biology’ as we (the authors) understand it, as outlined below. Systems biology combines quantitative ... carboxykinase and PEP synthase. Likewise, pathway analysis suggests that the TCA cycle enzymes citrate synthase and succinate dehydrogenase are essential for all growth substrat...

Ngày tải lên: 14/02/2014, 14:20

... DHSs can exist as either nucleosomes or conversely as nucleosome-free regions [85,86,200,223]. ChIP assays do not always adequately address this issue because they typically show that one of several ... chromatin states can exist, not that it is the only state at a specific DHS. Never- theless, for the most part it has been widely assumed that DHSs do represent nucleosome-free regions,...

Ngày tải lên: 14/02/2014, 18:20

... 8 complex and RNA helicase p68. The recruitment of the R-smads stimulates the production of these miR- NAs and thus represses the expression of their target genes. TGF-b signaling is known to ... neu signaling and that miR-21 suppresses the metastasis suppressor protein PDCD4 (programmed cell death 4) in breast cancer cells. The expression of miR-21 is also upregulated by...

Ngày tải lên: 14/02/2014, 19:20

... arrest and apopto- sis and suppresses cell growth and metastasis, possibly by silencing these target genes [28,33,37,39–41]. miR-124 Many studies have shown that mature miR-124 is the most abundant ... not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. F. Sato et al. MicroRNAs and e...

Ngày tải lên: 14/02/2014, 19:20

... injury, but also contributes to the initiation and progression of atherosclerosis [103,104]. The response-to-injury hypothesis proposed that endothelial dysfunction caused by, for example, elevated ... demonstrated that the angiotensin II type 1 receptor (AT1R) and miR-155 are coexpressed in endothelial cells and VSMCs, and that miR-155 translationally represses the expres...

Ngày tải lên: 14/02/2014, 19:20

... various stable mis- folded proteins leads to the formation of aggregates and inclusion bodies in the cell. Parkinson s disease, Alzheimer s disease, Huntington s disease, prion dis- ease, etc. ... increase in time of incubation, the intensity of the band for the monomeric protein decreased, whereas the bands for the higher molecular mass aggregates intensified. This co...

Ngày tải lên: 14/02/2014, 19:20