Tài liệu Báo cáo khoa học: Proteolytic processing regulates pathological accumulation in dentatorubral-pallidoluysian atrophy pdf

... plays a principal role in the pathological accumulation of ATN1 in dentatorubral-pallidoluysian atrophy. Abbreviations ALLN, N-acetyl-Leu-Leu-norleucinal; ATN1, atrophin-1; DRPLA, dentatorubral-pallidoluysian ... huntingtin. Cell 125, 1179–1191. 26 Yazawa I, Nakase H & Kurisaki H (1999) Abnormal dentatorubral-pallidoluysian atrophy (DRPLA) protein complex is pathological...

Ngày tải lên: 15/02/2014, 01:20

... recall gains on the minority classes. 1 Introduction Since the beginning of the new millennium, there has been a growing need in the medical community for Natural Language Processing (NLP) ... by manually examining the training data: Lexical Features: The medical term itself, the three words preceding it, and the three words fol- lowing it. We used the LVG annotator in Lexical...

Ngày tải lên: 20/02/2014, 05:20

... use the erythropoietin receptor (EpoR)-induced activation of ERK1 in the hematopoietic suspension cell line, BaF3-hemaglutinin-tagged (HA)-EpoR, and the interleukin-6 (IL-6)-induced activation ... while blotting errors are caused by inhomogeneities of the gel or the blot. Eliminating correlated errors by randomized sample loading To determine steps predominantly contributing to the error ob...

Ngày tải lên: 19/02/2014, 07:20

... a minor role in brain energetics. Although most cells containing mitochon- dria maintain some ability to beta-oxidize long-chain fatty acids, adult neurons do not robustly oxidize long-chain ... shown to bind malo- nyl-CoA [47]. Interestingly, its tissue distribution was restricted to the brain. Being a malonyl-CoA binding protein that is restricted to neurons made it a tantaliz- ing effect...

Ngày tải lên: 14/02/2014, 22:20

... thdng tuc, tham chf thd thien. Ching ban, vd xung hd, cd the dting: may, tao, cau, td, minh, chiing minh, bpn minh, y, bin, bin ta, bpn nd, tui nd, thing, thing cha, con me, mu, con mu, mu ... Trong qua trinh phit trien ciia ngdn ngir va xa hdi, cic phong cich chirc nang, cic ling xu ngdn ngir trong nhirng hoan cinh giao tiep kbic nhau dupc hinh thanh va nhan dien din din. Giao tie...

Ngày tải lên: 18/02/2014, 03:20

... of the coronal section at E14.5 in (F). (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline. Surprisingly, the HSF2 expression pattern ... birth in mouse brains [122,124]. No HSF4 DNA-binding activity was reported in the developing mouse brain so far. How- ever, Hsf4b is expressed in the adult mouse brain, including ce...

Ngày tải lên: 18/02/2014, 04:20

... electron acceptor ferredoxin is suspected to bind. Electron tunneling is likely to proceed dominantly in a through-bond mechanism involving the backbone and coordinating cysteinyl ligands of the iron-sulfur ... (1998) Thiamin-dependent enzymes. In Comprehensive Biological Catalysis (Sinnott ML, ed.), pp. 217–266. Academic Press, London. 2 Perham RN (2000) Swinging arms and swinging domain...

Ngày tải lên: 18/02/2014, 08:20

... differentiation was initiated at 48 h post-transfection by maintaining the cells in culture medium containing 2% horse serum. Cells were fixed on day 4 of differentiation and stained with hematoxylin and eosin. ... cluster, including miR-17-5p, miR-20, and miR-92, were upreg- ulated during differentiation (Fig. 1A, right panel). We further investigated the kinetics of miR-27 expression durin...

Ngày tải lên: 18/02/2014, 08:20

... thought by providing just such an interdisciplinary forum, in which research results, including novel concepts such as environmen- tally induced increases in mutation rates in bacteria and a ... gene regulons and regulatory pathways involved in freezing tolerance in Arabidopsis. Freezing tolerance increases in many plants in response to low, non-freezing temperature, a process k...

Ngày tải lên: 18/02/2014, 11:20

... their inhibitors in several cell lines [10]. The protein itself has no known enzymatic activity, but binds to distinct intracellular target proteins and regulates specific func- tions involved in tumour ... regarding the role of the aVb3 integrin, because it is also reported to suppress collagen I-induced activation of proMMP-2 [8]. Another MMP inhibitor, reversion-inducing cysteine- ric...

Ngày tải lên: 18/02/2014, 11:20